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Influences of endocrine and autocrine factors in normal and neoplastic ovarian surface epithelium

https://libraries.phsa.ca/permalink/catalog113974

http://hdl.handle.net/2429/13688

Choi, Kyung-Chul. Vancouver, BC: University of British Columbia , 2001. (Thesis)
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death i…
Title
Influences of endocrine and autocrine factors in normal and neoplastic ovarian surface epithelium
Author
Choi, Kyung-Chul
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2001
Topics
Faculty of Medicine
Theses
Abstract
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death in gynecological malignancies. Repeated ovulation contributes to neoplastic transformation of OSE, indicating that the process of healing ruptured OSE may contribute to the disease. Therefore, it has been hypothesized that endocrine and autocrine factors may influence the occurrence of ovarian tumors in women.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/13688
Audience
Professional
Call Number
Thesis Shelf

Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells

https://libraries.phsa.ca/permalink/catalog113978

http://hdl.handle.net/2429/6315

Chen, Victor. Vancouver, BC: University of British Columbia , 1997. (Thesis)
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type…
Title
Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells
Author
Chen, Victor
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1997
Topics
Faculty of Medicine
Theses
Abstract
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6315
Audience
Professional
Call Number
Thesis Shelf