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Monte Carlo modelling of peripheral dose and risk of secondary malignancy in flattening-filter-free and 10 MV photon beams for paediatric radiotherapy

https://libraries.phsa.ca/permalink/catalog121967

https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0379814

Ben Bouchta, Youssef. Vancouver, BC: University of British Columbia , 2019. (Book, Thesis, Online)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 B456 2019
Title
Monte Carlo modelling of peripheral dose and risk of secondary malignancy in flattening-filter-free and 10 MV photon beams for paediatric radiotherapy
Author
Ben Bouchta, Youssef
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2019
Subjects
Radiotherapy
Radiation Dosage
Neoplasms - complications
Child
Cancer Survivors
Secondary Prevention
Thesis
Language
English
Material Type
Book
Thesis
Online
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0379814
Audience
Professional
Call Number
LE3 B456 2019

Exploring equitably high quality cancer survivorship care

https://libraries.phsa.ca/permalink/catalog121193

http://hdl.handle.net/2429/66694

Truant, Tracy L. O. Vancouver, BC: University of British Columbia , 2018. (Thesis, Ebook)
Audience
Professional
Agency
BC Cancer Agency
Location
Internet
Title
Exploring equitably high quality cancer survivorship care
Author
Truant, Tracy L. O.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2018
Subjects
Cancer Survivors
Healthcare Disparities
Canada
Language
English
Material Type
Thesis
Ebook
Agency
BC Cancer Agency
Location
Internet
URL
http://hdl.handle.net/2429/66694
Audience
Professional

Monte Carlo dosimetry of total body irradiation

https://libraries.phsa.ca/permalink/catalog121966

https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0365701

Burns, Levi. Vancouver, BC: University of British Columbia , 2018. (Book, Thesis, Online)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 B967 2018
Title
Monte Carlo dosimetry of total body irradiation
Author
Burns, Levi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2018
Subjects
Whole-Body Irradiation - methods
Radiometry
Radiotherapy
Thesis
Language
English
Material Type
Book
Thesis
Online
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0365701
Audience
Professional
Call Number
LE3 B967 2018

Epidemiology, diagnosis and treatment of cerebral venous thrombosis

https://libraries.phsa.ca/permalink/catalog113273
Coutinho, Jonathan. Amsterdam, Netherlands: , 2014. Published thesis. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
REF FM 340 COU 2014
This thesis is divided into two parts: the first describes studies on the epidemiology and diagnosis of CVT (Cerebral venous thrombosis); and the second part focuses on the normal developments in the treatments of CVT.
Title
Epidemiology, diagnosis and treatment of cerebral venous thrombosis
Author
Coutinho, Jonathan
Edition
Published thesis
Place
Amsterdam, Netherlands
Year Published
2014
Physical Description
Paperback: 253 pages
Topics
Stroke
Brain
Abstract
This thesis is divided into two parts: the first describes studies on the epidemiology and diagnosis of CVT (Cerebral venous thrombosis); and the second part focuses on the normal developments in the treatments of CVT.
ISBN
9789064647536
Language
English
Material Type
Book
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
Audience
Professional
Call Number
REF FM 340 COU 2014
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
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18F-FDOPA positron emission tomography and diffusion tensor imaging for radiation therapy of high-grade gliomas with dose painting

https://libraries.phsa.ca/permalink/catalog121964

https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0166880

Kosztyla, Robert. Vancouver, BC: University of British Columbia , 2014. (Book, Thesis, Online)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 K86 2014
Title
18F-FDOPA positron emission tomography and diffusion tensor imaging for radiation therapy of high-grade gliomas with dose painting
Author
Kosztyla, Robert
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2014
Subjects
Radiotherapy
Radiation Dosage
Thesis
Language
English
Material Type
Book
Thesis
Online
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0166880
Audience
Professional
Call Number
LE3 K86 2014

Developing quality assurance procedures for gated volumetric modulated arc therapy in stereotactic ablativive radiation therapy

https://libraries.phsa.ca/permalink/catalog121965

https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072169

Viel, Francis. Vancouver, BC: University of British Columbia , 2014. (Book, Thesis, Online)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 V659 2014
Title
Developing quality assurance procedures for gated volumetric modulated arc therapy in stereotactic ablativive radiation therapy
Author
Viel, Francis
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2014
Subjects
Liver Neoplasms - radiotherapy
Radiotherapy, Intensity-Modulated
Quality Assurance, Health Care
Thesis
Language
English
Material Type
Book
Thesis
Online
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072169
Audience
Professional
Call Number
LE3 V659 2014

Dynamic gene expression patterns during in vivo maturation of mouse hepatoblasts

https://libraries.phsa.ca/permalink/catalog21281
Lee, Sam Chi-Hang. Vancouver, BC: University of British Columbia , 2013. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2013 L477
Title
Dynamic gene expression patterns during in vivo maturation of mouse hepatoblasts
Author
Lee, Sam Chi-Hang
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Subjects
Gene Expression
Mice - genetics
Hepatocytes
Transcriptome
Cell Differentiation - genetics
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2013 L477
c.1 BC Cancer Agency VC Library Available

Developmental changes in the properties of mouse mammary stem cells

https://libraries.phsa.ca/permalink/catalog21284
Makarem, Maisam. Vancouver, BC: University of British Columbia , 2013. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2013 M235
Title
Developmental changes in the properties of mouse mammary stem cells
Author
Makarem, Maisam
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Subjects
Stem Cells - cytology
Mice
Cell Growth Processes
Mammary Glands, Animal - embryology
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2013 M235
c.1 BC Cancer Agency VC Library Available

Profiling the vaginal microbiome in HIV-positive women

https://libraries.phsa.ca/permalink/catalog113942

http://hdl.handle.net/2429/44267

Mahal, Daljeet Singh. Vancouver, BC: University of British Columbia , 2013. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Title
Profiling the vaginal microbiome in HIV-positive women
Author
Mahal, Daljeet Singh
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Topics
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/44267
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration

https://libraries.phsa.ca/permalink/catalog113943

http://hdl.handle.net/2429/44653

Nguyen, Tuan-Anh Thi. Vancouver, BC: University of British Columbia , 2013. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Title
Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration
Author
Nguyen, Tuan-Anh Thi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Topics
Faculty of Medicine
Theses
Abstract
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/44653
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Four dimensional volumetric modulated arc therapy planning system for stereotactic body radiation therapy in lung cancers

https://libraries.phsa.ca/permalink/catalog21322

https://circle.ubc.ca/handle/2429/44048

Chin, Erika Ming Yee. Vancouver, BC: University of British Columbia , 2013. (Book, Online, Thesis)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 C539 2013
Title
Four dimensional volumetric modulated arc therapy planning system for stereotactic body radiation therapy in lung cancers
Author
Chin, Erika Ming Yee
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Subjects
Radiotherapy, Intensity-Modulated
Radiosurgery - methods
Lung Neoplasms - radiotherapy
Thesis
Language
English
Material Type
Book
Online
Thesis
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://circle.ubc.ca/handle/2429/44048
Audience
Professional
Call Number
LE3 C539 2013

Natural helper cell development and their role in mediating the innate Th2 inflammatory response

https://libraries.phsa.ca/permalink/catalog21272
Halim, Timotheus You Fu. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 H173
Title
Natural helper cell development and their role in mediating the innate Th2 inflammatory response
Author
Halim, Timotheus You Fu
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Th2 Cells - immunology
Allergens - immunology
T-Lymphocytes, Helper-Inducer
Lung - immunology
Nuclear Receptor Subfamily 1, Group F, Member 1
Mice
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 H173
c.1 BC Cancer Agency VC Library Available

Computational exploratory analysis of high-dimensional flow cytometry data for diagnosis and biomarker discovery

https://libraries.phsa.ca/permalink/catalog21278
Aghaeepour, Nima. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 A266
Title
Computational exploratory analysis of high-dimensional flow cytometry data for diagnosis and biomarker discovery
Author
Aghaeepour, Nima
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Flow Cytometry - methods
Computational Biology
Biological Markers
Automation, Laboratory
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 A266
c.1 BC Cancer Agency VC Library Available

Manipulating the tumor microenvironment to slow cancer growth

https://libraries.phsa.ca/permalink/catalog21279
Ho, Victor Wing Heng. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 H678
Title
Manipulating the tumor microenvironment to slow cancer growth
Author
Ho, Victor Wing Heng
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Tumor Microenvironment
Neoplastic Processes
Neoplasms - metabolism
Neoplasms - pathology
Energy Metabolism
Macrophage Activation
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 H678
c.1 BC Cancer Agency VC Library Available

Transcription regulation of two natural killer cell activating receptors, NKG2D and NCR1

https://libraries.phsa.ca/permalink/catalog21280
Lai, Chieh Min. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 L185
Title
Transcription regulation of two natural killer cell activating receptors, NKG2D and NCR1
Author
Lai, Chieh Min
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Killer Cells, Natural
Transcription, Genetic
Natural Cytotoxicity Triggering Receptor 1
NK Cell Lectin-Like Receptor Subfamily K
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 L185
c.1 BC Cancer Agency VC Library Available

Telomere resolution and genomic instability in mouse embryonic stem cells

https://libraries.phsa.ca/permalink/catalog21282
Lisaingo, Kathleen. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 L769
Title
Telomere resolution and genomic instability in mouse embryonic stem cells
Author
Lisaingo, Kathleen
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Telomere - genetics
Mice
Genomic Instability
Embryonic Stem Cells
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 L769
c.1 BC Cancer Agency VC Library Available

Computational techniques for flow cytometry : the application for automated analysis of innate immune response flow cytometry data

https://libraries.phsa.ca/permalink/catalog21283
Shooshtari, Parisa. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 S559
Title
Computational techniques for flow cytometry : the application for automated analysis of innate immune response flow cytometry data
Author
Shooshtari, Parisa
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Flow Cytometry - methods
Computational Biology
Automation, Laboratory
Immunophenotyping
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 S559
c.1 BC Cancer Agency VC Library Available

Computational studies of the genome dynamics of mammalian transposable elements and their relationships to genes

https://libraries.phsa.ca/permalink/catalog21285
Zhang, Ying. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 Z63
Title
Computational studies of the genome dynamics of mammalian transposable elements and their relationships to genes
Author
Zhang, Ying
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
DNA Transposable Elements
Genomics
Endogenous Retroviruses
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 Z63
c.1 BC Cancer Agency VC Library Available

Development and application of an in vitro culture model for primary human T-all cells

https://libraries.phsa.ca/permalink/catalog21286
Yost, Arla June. Vancouver, BC: University of British Columbia , 2012. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2012 Y65
Title
Development and application of an in vitro culture model for primary human T-all cells
Author
Yost, Arla June
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Subjects
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Models, Biological
Cell Culture Techniques
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2012 Y65
c.1 BC Cancer Agency VC Library Available

Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://libraries.phsa.ca/permalink/catalog113944

http://hdl.handle.net/2429/42242

So, Wai Kin. Vancouver, BC: University of British Columbia , 2012. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Title
Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells
Author
So, Wai Kin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Topics
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/42242
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://libraries.phsa.ca/permalink/catalog113945

http://hdl.handle.net/2429/42609

Wu, Elizabeth Xianshi. Vancouver, BC: University of British Columbia , 2012. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Title
X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)
Author
Wu, Elizabeth Xianshi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Topics
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/42609
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://libraries.phsa.ca/permalink/catalog113946

http://hdl.handle.net/2429/43273

Asghari Roodsari, Alaleh. Vancouver, BC: University of British Columbia , 2012. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Title
Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy
Author
Asghari Roodsari, Alaleh
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Topics
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/43273
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Experience of well-being in the midst of advanced cancer

https://libraries.phsa.ca/permalink/catalog20211
Yue, Kathleen. Victoria, BC: University of Victoria , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Victoria Library
Call Number
LE3 2011 Y94
Title
Experience of well-being in the midst of advanced cancer
Author
Yue, Kathleen
Place
Victoria, BC
Publisher
University of Victoria
Year Published
2011
Subjects
Neoplasms - complications
Terminal Care
Palliative Care
Personal Satisfaction
Quality of Life
Neoplasms - psychology
Neoplasms - nursing
Adaptation, Psychological
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Victoria Library
Audience
Professional
Call Number
LE3 2011 Y94
c.1 BC Cancer Agency VIC Library Available

Telomere length and dynamics in Hutchinson-Gilford progeria syndrome

https://libraries.phsa.ca/permalink/catalog20509
Decker, Michelle Leanna. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 D295
Title
Telomere length and dynamics in Hutchinson-Gilford progeria syndrome
Author
Decker, Michelle Leanna
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Telomere
Progeria - genetics
Lamin Type A
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 D295
c.1 BC Cancer Agency VC Library Available

Flow cytometry analysis and sorting of chromosomes following hybridization with fluorescent probes that target specifiv DNA repeat sequences

https://libraries.phsa.ca/permalink/catalog20510
Brind'Amour, Julie. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 B858
Title
Flow cytometry analysis and sorting of chromosomes following hybridization with fluorescent probes that target specifiv DNA repeat sequences
Author
Brind'Amour, Julie
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Flow Cytometry - methods
Chromosomes - genetics
DNA - genetics
In Situ Hybridization, Fluorescence
Repetitive Sequences, Nucleic Acid
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 B858
c.1 BC Cancer Agency VC Library Available

More efficient killing machine : how CpG-oligodeoxynucleotides enhance natural killer cell cytokine production and cytotoxicity against leukemia initiating cells

https://libraries.phsa.ca/permalink/catalog20511
Guillon, Laura Katharine. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 G961
Title
More efficient killing machine : how CpG-oligodeoxynucleotides enhance natural killer cell cytokine production and cytotoxicity against leukemia initiating cells
Author
Guillon, Laura Katharine
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Killer Cells, Natural
Leukemia, Myeloid, Acute - therapy
Oligodeoxyribonucleotides - therapeutic use
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 G961
c.1 BC Cancer Agency VC Library Available

Who's the boss? an investigation into the complex relationship between endogenous retroviruses and nearby genes

https://libraries.phsa.ca/permalink/catalog20512
Miceli, Katharine Elizabeth. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 M619
Title
Who's the boss? an investigation into the complex relationship between endogenous retroviruses and nearby genes
Author
Miceli, Katharine Elizabeth
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Endogenous Retroviruses
Mice - genetics
DNA Transposable Elements
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 M619
c.1 BC Cancer Agency VC Library Available

Role of SHIP in natural killer cell licensing

https://libraries.phsa.ca/permalink/catalog20513
Rytova, Valeria. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 R997
Title
Role of SHIP in natural killer cell licensing
Author
Rytova, Valeria
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Killer Cells, Natural
Shc Signaling Adaptor Proteins
Ly49G2 receptor
Genes, MHC Class I
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 R997
c.1 BC Cancer Agency VC Library Available

Characterization of mouse hematopoietic stem cells primed to actively self-renew by NUP98-HOXA10hd fusion gene

https://libraries.phsa.ca/permalink/catalog20514
Sekulovic, Sanja. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 S463
Title
Characterization of mouse hematopoietic stem cells primed to actively self-renew by NUP98-HOXA10hd fusion gene
Author
Sekulovic, Sanja
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Hematopoietic Stem Cells - cytology
Nuclear Pore Complex Proteins
Homeodomain Proteins - genetics
Recombinant Fusion Proteins - genetics
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 S463
c.1 BC Cancer Agency VC Library Available

Automatic analysis of flow cytometry data and its application to lymphoma diagnosis

https://libraries.phsa.ca/permalink/catalog20515
Zare, Habil. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 Z36
Title
Automatic analysis of flow cytometry data and its application to lymphoma diagnosis
Author
Zare, Habil
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Flow Cytometry - methods
Lymphoma, Mantle-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell
Algorithms
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 Z36
c.1 BC Cancer Agency VC Library Available

Strategies for improving the therapeutic and diagnostic approaches to acute leukemias

https://libraries.phsa.ca/permalink/catalog20516
Kim, Hyun Pyo. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 K49
Title
Strategies for improving the therapeutic and diagnostic approaches to acute leukemias
Author
Kim, Hyun Pyo
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Leukemia, Myeloid, Acute
Leukemia, Lymphoid
Protein-Tyrosine Kinases
Lymphoid Progenitor Cells - drug effects
Mitoxantrone
Drug Resistance
Bone Marrow Cells - drug effects
Diptheria Toxin - therapeutic use
Liposomes
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 K49
c.1 BC Cancer Agency VC Library Available

Immunosuppressive myeloid cells under normal and neoplastic conditions

https://libraries.phsa.ca/permalink/catalog20517
Hamilton, Melisa June. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 H219
Title
Immunosuppressive myeloid cells under normal and neoplastic conditions
Author
Hamilton, Melisa June
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Myeloid Cells - immunology
Macrophages
Toll-Like Receptors
Immunosuppression
Mice
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 H219
c.1 BC Cancer Agency VC Library Available

In vivo detection of G-quadruplex nucleic acids using monoclonal antibodies

https://libraries.phsa.ca/permalink/catalog20518
Henderson, Alexander. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 H496
Title
In vivo detection of G-quadruplex nucleic acids using monoclonal antibodies
Author
Henderson, Alexander
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
G-Quadruplexes
Antibodies, Monoclonal
Nucleic Acid Conformation
Hybridomas
DNA - chemistry
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 H496
c.1 BC Cancer Agency VC Library Available

Analysis of hematopoiesis from human pluripotent stem cells

https://libraries.phsa.ca/permalink/catalog20519
Kardel, Melanie Dawn. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 K18
Title
Analysis of hematopoiesis from human pluripotent stem cells
Author
Kardel, Melanie Dawn
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Hematopoiesis
Pluripotent Stem Cells
Stem Cells
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 K18
c.1 BC Cancer Agency VC Library Available

Detection and characterization of human mammary stem cells

https://libraries.phsa.ca/permalink/catalog20520
Eirew, Peter. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2011 E34
Title
Detection and characterization of human mammary stem cells
Author
Eirew, Peter
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Mammary Glands, Human - cytology
Stem Cells
Cell Separation
Cell Differentiation
Phenotype
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2011 E34
c.1 BC Cancer Agency VC Library Available

Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://libraries.phsa.ca/permalink/catalog113947

http://hdl.handle.net/2429/31191

Sakian, Sina. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Title
Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)
Author
Sakian, Sina
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/31191
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulation of androgen action by sex hormone-binding globulin

https://libraries.phsa.ca/permalink/catalog113948

http://hdl.handle.net/2429/35861

Hong, Eui-ju. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Title
Regulation of androgen action by sex hormone-binding globulin
Author
Hong, Eui-ju
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/35861
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Investigation of confined placental mosaicism and aberrant H19/ IGF2 imprinting in pregnancies conceived by in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)

https://libraries.phsa.ca/permalink/catalog113955

http://hdl.handle.net/2429/33832

Chan Wong, Edgar Antonio. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. H…
Title
Investigation of confined placental mosaicism and aberrant H19/ IGF2 imprinting in pregnancies conceived by in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)
Author
Chan Wong, Edgar Antonio
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. However, IVF and ICSI have been associated with increased risks of adverse perinatal health outcomes. The higher risk of low birth weight, intrauterine growth restriction, and small for gestational age are of special concern due to its association with adult-onset diseases. In this thesis project, the effect of ART on the genetic and epigenetic status of the placenta, and their associations with fetal growth restriction are examined.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/33832
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Implementation of respiratory-correlated cone-beam CT on Varian linac systems

https://libraries.phsa.ca/permalink/catalog121959

https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072204

Cropp, Robert. Vancouver, BC: University of British Columbia , 2011. (Book, Thesis, Online)
Audience
Professional
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
Call Number
LE3 C948 2011
Title
Implementation of respiratory-correlated cone-beam CT on Varian linac systems
Author
Cropp, Robert
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Subjects
Cone-Beam Computed Tomography
Radiotherapy
Thesis
Language
English
Material Type
Book
Thesis
Online
Agency
BC Cancer Agency
Location
VC Medical Physics
Internet
URL
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072204
Audience
Professional
Call Number
LE3 C948 2011

The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://libraries.phsa.ca/permalink/catalog113949

http://hdl.handle.net/2429/29783

Zou, Junxuan. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Title
The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro
Author
Zou, Junxuan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29783
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://libraries.phsa.ca/permalink/catalog113950

http://hdl.handle.net/2429/29282

Minor, Agata. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Title
DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility
Author
Minor, Agata
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29282
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://libraries.phsa.ca/permalink/catalog113951

http://hdl.handle.net/2429/28961

Shi, Fengtao. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Title
Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells
Author
Shi, Fengtao
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28961
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone

https://libraries.phsa.ca/permalink/catalog113952

http://hdl.handle.net/2429/34980

Chen, Junling. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
Title
Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone
Author
Chen, Junling
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/34980
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://libraries.phsa.ca/permalink/catalog113953

http://hdl.handle.net/2429/30021

Poon, Song Ling. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
Title
Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role
Author
Poon, Song Ling
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30021
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons REF Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://libraries.phsa.ca/permalink/catalog113954

http://hdl.handle.net/2429/30478

Wen, Jiadi. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Title
Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology
Author
Wen, Jiadi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30478
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Automated analysis of high-throughput flow cytometry data from hematopoietic stem cell experiments

https://libraries.phsa.ca/permalink/catalog18633
Cortes, Sergio Adrian. Vancouver, BC: University of British Columbia , 2010. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2010 C828
Title
Automated analysis of high-throughput flow cytometry data from hematopoietic stem cell experiments
Author
Cortes, Sergio Adrian
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Subjects
Flow Cytometry
Hematopoietic Stem Cells
Computational Biology - methods
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2010 C828
c.1 BC Cancer Agency VC Library Available

Novel oncogene AHI-1 interacts with BCR-ABL and JAK2 and mediates cellular resistance to tyrosine kinase inhibitors in CML

https://libraries.phsa.ca/permalink/catalog19878
DeGeer, Donna. Vancouver, BC: University of British Columbia , 2010. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2010 D317
Title
Novel oncogene AHI-1 interacts with BCR-ABL and JAK2 and mediates cellular resistance to tyrosine kinase inhibitors in CML
Author
DeGeer, Donna
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Subjects
Oncogenes - genetics
AHI1 protein, human
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
JAK2 protein, human
Protein Kinase Inhibitors
Tyrosine
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2010 D317
c.1 BC Cancer Agency VC Library Available

Genomic analysis of embryonic heart development in the mouse

https://libraries.phsa.ca/permalink/catalog19880
Vrljicak, Pavle Josip. Vancouver, BC: University of British Columbia , 2010. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2010 P338
Title
Genomic analysis of embryonic heart development in the mouse
Author
Vrljicak, Pavle Josip
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Subjects
Embryonic Development - genetics
Heart Defects, Congenital
Mice - embryology
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2010 P338
c.1 BC Cancer Agency VC Library Available

Role of talin in LFA-1 function in cell-mediated cytotoxicity

https://libraries.phsa.ca/permalink/catalog19881
Mace, Emily Margaret. Vancouver, BC: University of British Columbia , 2010. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2010 M141
Title
Role of talin in LFA-1 function in cell-mediated cytotoxicity
Author
Mace, Emily Margaret
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Subjects
Lymphocyte Function-Associated Antigen-1
Talin - physiology
T-Lymphocytes, Cytotoxic
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2010 M141
c.1 BC Cancer Agency VC Library Available

B cells as regulators of natural killer cell IFN-y production in mice

https://libraries.phsa.ca/permalink/catalog19883
Haddad, Evette. Vancouver, BC: University of British Columbia , 2010. (Book, Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Cancer Agency
Location
Vancouver Library
Call Number
LE3 2010 H126
Title
B cells as regulators of natural killer cell IFN-y production in mice
Author
Haddad, Evette
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Subjects
Killer Cells, Natural
B-Lymphocytes - immunology
Interferon-gamma
Mice - genetics
Language
English
Material Type
Book
Thesis
Agency
BC Cancer Agency
Location
Vancouver Library
Audience
Professional
Call Number
LE3 2010 H126
c.1 BC Cancer Agency VC Library Available

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