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The maternal predisposition to the syndrome of pre-eclampsia

https://libraries.phsa.ca/permalink/catalog113968

http://hdl.handle.net/2429/15429

Alasaly, Kadria A. Vancouver, BC: University of British Columbia , 2004. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine …
Title
The maternal predisposition to the syndrome of pre-eclampsia
Author
Alasaly, Kadria A.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2004
Topics
Faculty of Medicine
Theses
Abstract
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine growth restriction (IUGR). IUGR can occur in isolation, so-called normotensive IUGR. What is poorly understood is that some women develop the maternal syndrome of pre-eclampsia whilst others have only the fetal syndrome (normotensive IUGR), despite the fact that the initiating event in both is believed to be reduced uteroplacental perfusion.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/15429
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The role of norepinephrine in the neuroendocrine regulation of luteinizing hormone release in the rat

https://libraries.phsa.ca/permalink/catalog113999

http://hdl.handle.net/2429/28623

Bergen, Hugo Theodore. Vancouver, BC: University of British Columbia , 1988. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
An excitatory role for norepinephrine (NE) in the regulation of luteinizing hormone (LH) release was first suggested when it was demonstrated that noradrenergic receptor antagonists were able to block ovulation. More recently it has been proposed that NE has both an excitatory role and an inhibitor…
Title
The role of norepinephrine in the neuroendocrine regulation of luteinizing hormone release in the rat
Author
Bergen, Hugo Theodore
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1988
Topics
Faculty of Medicine
Theses
Abstract
An excitatory role for norepinephrine (NE) in the regulation of luteinizing hormone (LH) release was first suggested when it was demonstrated that noradrenergic receptor antagonists were able to block ovulation. More recently it has been proposed that NE has both an excitatory role and an inhibitory role in the neuroendocrine regulation of LH release. The excitatory effects may be mediated by alpha-adrenergic receptors and the inhibitory effects may be mediated via beta-adrenergic receptors. These experiments were performed to better understand the role of NE, the receptor type through which NE exerts its effects, and the role of the two major NE pathways in the brain, on LH secretion in the rat.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28623
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb

https://libraries.phsa.ca/permalink/catalog114000

http://hdl.handle.net/2429/30417

Van der Weyde, Marlene. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral…
Title
The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb
Author
Van der Weyde, Marlene
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a fetal femoral artery, umbilical vein, maternal femoral artery and uterine vein for the analysis of fetal and maternal arterial and umbilical and uterine venous blood gases, acid-base status, hematocrit, ritodrine concentration, uterine and umbilical blood flow, and glucose, lactate and oxygen concentrations and fluxes.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30417
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The molecular biology of calbindin-D9k

https://libraries.phsa.ca/permalink/catalog113987

http://hdl.handle.net/2429/1766

Jeung, Eui-Bae. Vancouver, BC: University of British Columbia , 1993. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calb…
Title
The molecular biology of calbindin-D9k
Author
Jeung, Eui-Bae
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1993
Topics
Faculty of Medicine
Theses
Abstract
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calbindin-D9k at the cDNA and genomic level. The cDNAs for the bovine, murine, and ratcalbindin-D9k as well as the gene for rat calbindin-D9k had been cloned previously.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/1766
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://libraries.phsa.ca/permalink/catalog113949

http://hdl.handle.net/2429/29783

Zou, Junxuan. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Title
The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro
Author
Zou, Junxuan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29783
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level

https://libraries.phsa.ca/permalink/catalog113982

http://hdl.handle.net/2429/7255

Fan, Nancy C. Vancouver, BC: University of British Columbia , 1995. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
Title
Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level
Author
Fan, Nancy C.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1995
Topics
Faculty of Medicine
Theses
Abstract
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/7255
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Profiling the vaginal microbiome in HIV-positive women

https://libraries.phsa.ca/permalink/catalog113942

http://hdl.handle.net/2429/44267

Mahal, Daljeet Singh. Vancouver, BC: University of British Columbia , 2013. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Title
Profiling the vaginal microbiome in HIV-positive women
Author
Mahal, Daljeet Singh
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Topics
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/44267
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The prediction of adverse maternal outcomes in pre-eclampsia

https://libraries.phsa.ca/permalink/catalog113966

http://hdl.handle.net/2429/16403

Devarakonda, Rajashree M. Vancouver, BC: University of British Columbia , 2005. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility …
Title
The prediction of adverse maternal outcomes in pre-eclampsia
Author
Devarakonda, Rajashree M.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2005
Topics
Faculty of Medicine
Theses
Abstract
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility of developing a severity score that can predict adverse maternal outcome.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/16403
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of clomiphene citrate on ovarian function in rats

https://libraries.phsa.ca/permalink/catalog113993

http://hdl.handle.net/2429/28984

Feng, Tian Bin. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG a…
Title
The effects of clomiphene citrate on ovarian function in rats
Author
Feng, Tian Bin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28984
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Adamts expression in the human decidua of early pregnancy

https://libraries.phsa.ca/permalink/catalog113998

http://hdl.handle.net/2429/15632

Ng, York Hunt. Vancouver, BC: University of British Columbia , 2004. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The spatio-temporal expression of interleukin (IL)-1β and transforming growth factor (TGF)- β1 in the human endometrium suggests that these two cytokines act in concert with gonadal steroids to create a uterine environment that is capable of supporting a viable pregnancy. The highly regul…
Title
Adamts expression in the human decidua of early pregnancy
Author
Ng, York Hunt
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2004
Topics
Faculty of Medicine
Theses
Abstract
The spatio-temporal expression of interleukin (IL)-1β and transforming growth factor (TGF)- β1 in the human endometrium suggests that these two cytokines act in concert with gonadal steroids to create a uterine environment that is capable of supporting a viable pregnancy. The highly regulated series of developmental events that culminates in the terminal differentiation of the stromal cells into deciduas in preparation for implantation is mediated by alterations in the composition of the endometrial extracellular matrix (ECM). Consequently, matrix metalloproteinases have been assigned central roles in implantation and placentation.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/15632
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The role for insulin-like growth factor-I in preimplantation embryonic development and decidualization following superovulation in the rat

https://libraries.phsa.ca/permalink/catalog113980

http://hdl.handle.net/2429/4814

Katagiri, Seiji. Vancouver, BC: University of British Columbia , 1996. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation…
Title
The role for insulin-like growth factor-I in preimplantation embryonic development and decidualization following superovulation in the rat
Author
Katagiri, Seiji
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1996
Topics
Faculty of Medicine
Theses
Abstract
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation in the rat. IGF-I may be beneficial to preimplantation embryonic development. IGF-I stimulated embryonic development and metabolism in vitro and increased the rate of implantation and fetal development when the blastocysts were transferred into a receptive uterus.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/4814
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Expression and function of HOXA genes in the normal ovary and ovarian carcinoma

https://libraries.phsa.ca/permalink/catalog113963

http://hdl.handle.net/2429/30974

Ota, Takayo. Vancouver, BC: University of British Columbia , 2006. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epitheliu…
Title
Expression and function of HOXA genes in the normal ovary and ovarian carcinoma
Author
Ota, Takayo
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2006
Topics
Faculty of Medicine
Theses
Abstract
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epithelium (OSE). In contrast to other carcinomas, OSE differentiates further with neoplastic progression and acquires Mtillerian duct-derived epithelial properties. I tested the hypothesis that growth and differentiation in ovarian carcinogenesis are regulated by HOX genes.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30974
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells

https://libraries.phsa.ca/permalink/catalog113965

http://hdl.handle.net/2429/18509

Choi, Jung-Hye. Vancouver, BC: University of British Columbia , 2006. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is as…
Title
Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells
Author
Choi, Jung-Hye
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2006
Topics
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is associated with the development and progression of ovarian cancer. Exposure to excess gonadotropins and leptin, related to menopause or infertility therapy and obesity, respectively, has been implicated as a risk factor for ovarian cancer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/18509
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

A Biological role for GnRH I and GnRH II at the maternal-fetal interface

https://libraries.phsa.ca/permalink/catalog113971

http://hdl.handle.net/2429/14957

Zhou, Junshan. Vancouver, BC: University of British Columbia , 2003. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalance…
Title
A Biological role for GnRH I and GnRH II at the maternal-fetal interface
Author
Zhou, Junshan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2003
Topics
Faculty of Medicine
Theses
Abstract
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalanced by their respective endogenous inhibitors, plasminogen activator inhibitor (PAI-1) and tissue inhibitors of metalloproteinases (TIMPs) in both an autocrine and paracrine manner. To date, the factors capable of regulating the expression of uPA and MMP proteolytic systems at the maternal-fetal interface remain poorly characterized.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/14957
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons REF Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell

https://libraries.phsa.ca/permalink/catalog113976

http://hdl.handle.net/2429/6811

Vaananen, Jeffrey Eric. Vancouver, BC: University of British Columbia , 1997. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
Title
Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell
Author
Vaananen, Jeffrey Eric
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1997
Topics
Faculty of Medicine
Theses
Abstract
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6811
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb

https://libraries.phsa.ca/permalink/catalog113991

http://hdl.handle.net/2429/9896

Knight, Kathleen Elizaabeth. Vancouver, BC: University of British Columbia , 1998. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little …
Title
Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb
Author
Knight, Kathleen Elizaabeth
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1998
Topics
Faculty of Medicine
Theses
Abstract
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little research attention. Because the hindlimb is composed of skin, bone, and skeletal muscle, it is representative of the carcass
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/9896
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta

https://libraries.phsa.ca/permalink/catalog113994

http://hdl.handle.net/2429/29416

Little, Marie-Terese E. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol…
Title
The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta
Author
Little, Marie-Terese E.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol metabolism can be manipulated in early life. Therefore, studies of the developmental patterns of the key enzymes in cholesterol metabolism are of great importance. Acyl coenzyme A: cholesterol acyltransferase (ACAT) is the primary enzyme which catalyzes the conversion of free cholesterol to cholesterol esters in cells.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29416
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of superovulation on ovarian function and embryo development in rats

https://libraries.phsa.ca/permalink/catalog113997

http://hdl.handle.net/2429/29326

Yun, Young Won. Vancouver, BC: University of British Columbia , 1989. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference …
Title
The effects of superovulation on ovarian function and embryo development in rats
Author
Yun, Young Won
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1989
Topics
Faculty of Medicine
Theses
Abstract
This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference to ovarian steroid and circulating LH levels in immature rats treated with 4, 20 or 40 IU pregnant mare's serum gonadotropin (PMSG).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29326
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://libraries.phsa.ca/permalink/catalog113950

http://hdl.handle.net/2429/29282

Minor, Agata. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Title
DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility
Author
Minor, Agata
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29282
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.

https://libraries.phsa.ca/permalink/catalog113957

http://hdl.handle.net/2429/6844

Menzies, Jennifer Marie. Vancouver, BC: University of British Columbia , 2009. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to s…
Title
The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.
Author
Menzies, Jennifer Marie
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2009
Topics
Faculty of Medicine
Theses
Abstract
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6844
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

A morphological investigation of the effects of pregnant mare serum gonadotrophin on oocyte maturation, fertilization and embryonic development in rats

https://libraries.phsa.ca/permalink/catalog113990

http://hdl.handle.net/2429/30962

Britton, Ann Patricia. Vancouver, BC: University of British Columbia , 1991. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic a…
Title
A morphological investigation of the effects of pregnant mare serum gonadotrophin on oocyte maturation, fertilization and embryonic development in rats
Author
Britton, Ann Patricia
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1991
Topics
Faculty of Medicine
Theses
Abstract
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30962
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Inhibition of pulsatile luteinizing hormone release by atrial natriuretic peptide and brain natriuretic peptide in the ovariectomized rat

https://libraries.phsa.ca/permalink/catalog113992

http://hdl.handle.net/2429/29412

Zhang, Jin. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Atrial natriuretic peptide (ANP) of atrial myocyte origin, has been shown to play a role in the diuresis, natriuresis, and antagonism of angiotensin and vasopressin. However, it is now apparent that in addition to the production of the peptide in the heart and in its role in fluid and electrolyte h…
Title
Inhibition of pulsatile luteinizing hormone release by atrial natriuretic peptide and brain natriuretic peptide in the ovariectomized rat
Author
Zhang, Jin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Atrial natriuretic peptide (ANP) of atrial myocyte origin, has been shown to play a role in the diuresis, natriuresis, and antagonism of angiotensin and vasopressin. However, it is now apparent that in addition to the production of the peptide in the heart and in its role in fluid and electrolyte homeostasis, it is also produced in the central nervous system participating in the regulation of pituitary hormone secretion. Administration of ANP through both central and peripheral routes has been shown to inhibit secretion of luteinizing hormone (LH) in the gonadectomized rat model.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29412
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

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