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The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://libraries.phsa.ca/permalink/catalog113949

http://hdl.handle.net/2429/29783

Zou, Junxuan. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Title
The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro
Author
Zou, Junxuan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29783
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available