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Action of luteinizing hormone-releasing hormone in rat ovarian cells : hormone production and signal transduction

https://libraries.phsa.ca/permalink/catalog113996

http://hdl.handle.net/2429/29313

Wang, Jian. Vancouver, BC: University of British Columbia , 1989. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, tr…
Title
Action of luteinizing hormone-releasing hormone in rat ovarian cells : hormone production and signal transduction
Author
Wang, Jian
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1989
Topics
Faculty of Medicine
Theses
Abstract
The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, treatment with LHRH increased the accumulation of radiolabeled inositol lipids, diacylglycerol and free arachidonic acid, but luteinizing hormone (LH) or cholera toxin did not exert the same effect. Activation of protein kinase C by the phorbol ester, 12-0-tetradecanoyl phorbol-13-acetate (TPA) had a stimulatory action on membrane phosphoinositide breakdown.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29313
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Adamts expression in the human decidua of early pregnancy

https://libraries.phsa.ca/permalink/catalog113998

http://hdl.handle.net/2429/15632

Ng, York Hunt. Vancouver, BC: University of British Columbia , 2004. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The spatio-temporal expression of interleukin (IL)-1β and transforming growth factor (TGF)- β1 in the human endometrium suggests that these two cytokines act in concert with gonadal steroids to create a uterine environment that is capable of supporting a viable pregnancy. The highly regul…
Title
Adamts expression in the human decidua of early pregnancy
Author
Ng, York Hunt
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2004
Topics
Faculty of Medicine
Theses
Abstract
The spatio-temporal expression of interleukin (IL)-1β and transforming growth factor (TGF)- β1 in the human endometrium suggests that these two cytokines act in concert with gonadal steroids to create a uterine environment that is capable of supporting a viable pregnancy. The highly regulated series of developmental events that culminates in the terminal differentiation of the stromal cells into deciduas in preparation for implantation is mediated by alterations in the composition of the endometrial extracellular matrix (ECM). Consequently, matrix metalloproteinases have been assigned central roles in implantation and placentation.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/15632
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Aneuploidy and DNA fragmentation in morphologically abnormal sperm

https://libraries.phsa.ca/permalink/catalog113959

http://hdl.handle.net/2429/945

Tang, Steven Siu Yan. Vancouver, BC: University of British Columbia , 2008. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Intracytoplasmic sperm injection (ICSI) has been a successful assisted reproductive technique for men with severe male-factor infertility. However, ICSI requires the subjective selection of normal looking sperm, which does not preclude the transmission of genetically abnormal sperm. Correlation bet…
Title
Aneuploidy and DNA fragmentation in morphologically abnormal sperm
Author
Tang, Steven Siu Yan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2008
Topics
Faculty of Medicine
Theses
Abstract
Intracytoplasmic sperm injection (ICSI) has been a successful assisted reproductive technique for men with severe male-factor infertility. However, ICSI requires the subjective selection of normal looking sperm, which does not preclude the transmission of genetically abnormal sperm. Correlation between abnormal sperm morphology and chromosomal abnormalities has been suggested but not been conclusive and less is known about the connection between sperm morphology and DNA integrity. Sperm morphology will be evaluated on its ability to identify the level of chromosomal abnormalities or fragmented DNA in sperm. To further focus this investigation on sperm morphology, men with infertility isolated to abnormal sperm morphology (isolated teratozoopsermia) are examined.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/945
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

A Biological role for GnRH I and GnRH II at the maternal-fetal interface

https://libraries.phsa.ca/permalink/catalog113971

http://hdl.handle.net/2429/14957

Zhou, Junshan. Vancouver, BC: University of British Columbia , 2003. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalance…
Title
A Biological role for GnRH I and GnRH II at the maternal-fetal interface
Author
Zhou, Junshan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2003
Topics
Faculty of Medicine
Theses
Abstract
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalanced by their respective endogenous inhibitors, plasminogen activator inhibitor (PAI-1) and tissue inhibitors of metalloproteinases (TIMPs) in both an autocrine and paracrine manner. To date, the factors capable of regulating the expression of uPA and MMP proteolytic systems at the maternal-fetal interface remain poorly characterized.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/14957
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons REF Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration

https://libraries.phsa.ca/permalink/catalog113943

http://hdl.handle.net/2429/44653

Nguyen, Tuan-Anh Thi. Vancouver, BC: University of British Columbia , 2013. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Title
Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration
Author
Nguyen, Tuan-Anh Thi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Topics
Faculty of Medicine
Theses
Abstract
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/44653
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://libraries.phsa.ca/permalink/catalog113949

http://hdl.handle.net/2429/29783

Zou, Junxuan. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Title
The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro
Author
Zou, Junxuan
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29783
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level

https://libraries.phsa.ca/permalink/catalog113982

http://hdl.handle.net/2429/7255

Fan, Nancy C. Vancouver, BC: University of British Columbia , 1995. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
Title
Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level
Author
Fan, Nancy C.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1995
Topics
Faculty of Medicine
Theses
Abstract
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/7255
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Characterizations of a tumor-associated antigen COX-1

https://libraries.phsa.ca/permalink/catalog113988

http://hdl.handle.net/2429/30332

Sheu, Fong-Shyong. Vancouver, BC: University of British Columbia , 1991. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 K…
Title
Characterizations of a tumor-associated antigen COX-1
Author
Sheu, Fong-Shyong
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1991
Topics
Faculty of Medicine
Theses
Abstract
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 KD and exists as an aggregate in the natural- state. A highly purified COX-1 was obtained mainly by immunoaffirtity chromatography, with RP 215 as the affinity ligand, from the shed medium of cultured tumor cells.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30332
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities

https://libraries.phsa.ca/permalink/catalog113956

http://hdl.handle.net/2429/9705

Kirkpatrick, Gordon. Vancouver, BC: University of British Columbia , 2009. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosome…
Title
Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities
Author
Kirkpatrick, Gordon
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2009
Topics
Faculty of Medicine
Theses
Abstract
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/9705
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://libraries.phsa.ca/permalink/catalog113958

http://hdl.handle.net/2429/1395

Nguyen, Tuan-Anh T. Vancouver, BC: University of British Columbia , 2008. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…
Title
Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols
Author
Nguyen, Tuan-Anh T
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2008
Topics
Faculty of Medicine
Theses
Abstract
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/1395
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://libraries.phsa.ca/permalink/catalog113950

http://hdl.handle.net/2429/29282

Minor, Agata. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Title
DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility
Author
Minor, Agata
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29282
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

E-cadherin promotes tumorigenicity in human ovarian surface epithelium

https://libraries.phsa.ca/permalink/catalog113975

http://hdl.handle.net/2429/9760

Ong, Aldrich Dixon. Vancouver, BC: University of British Columbia , 1999. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence fo…
Title
E-cadherin promotes tumorigenicity in human ovarian surface epithelium
Author
Ong, Aldrich Dixon
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1999
Topics
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/9760
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://libraries.phsa.ca/permalink/catalog113951

http://hdl.handle.net/2429/28961

Shi, Fengtao. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Title
Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells
Author
Shi, Fengtao
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28961
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of clomiphene citrate on ovarian function in rats

https://libraries.phsa.ca/permalink/catalog113993

http://hdl.handle.net/2429/28984

Feng, Tian Bin. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG a…
Title
The effects of clomiphene citrate on ovarian function in rats
Author
Feng, Tian Bin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28984
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of superovulation on ovarian function and embryo development in rats

https://libraries.phsa.ca/permalink/catalog113997

http://hdl.handle.net/2429/29326

Yun, Young Won. Vancouver, BC: University of British Columbia , 1989. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference …
Title
The effects of superovulation on ovarian function and embryo development in rats
Author
Yun, Young Won
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1989
Topics
Faculty of Medicine
Theses
Abstract
This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference to ovarian steroid and circulating LH levels in immature rats treated with 4, 20 or 40 IU pregnant mare's serum gonadotropin (PMSG).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29326
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb

https://libraries.phsa.ca/permalink/catalog114000

http://hdl.handle.net/2429/30417

Van der Weyde, Marlene. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral…
Title
The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb
Author
Van der Weyde, Marlene
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a fetal femoral artery, umbilical vein, maternal femoral artery and uterine vein for the analysis of fetal and maternal arterial and umbilical and uterine venous blood gases, acid-base status, hematocrit, ritodrine concentration, uterine and umbilical blood flow, and glucose, lactate and oxygen concentrations and fluxes.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30417
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Expression and function of HOXA genes in the normal ovary and ovarian carcinoma

https://libraries.phsa.ca/permalink/catalog113963

http://hdl.handle.net/2429/30974

Ota, Takayo. Vancouver, BC: University of British Columbia , 2006. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epitheliu…
Title
Expression and function of HOXA genes in the normal ovary and ovarian carcinoma
Author
Ota, Takayo
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2006
Topics
Faculty of Medicine
Theses
Abstract
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epithelium (OSE). In contrast to other carcinomas, OSE differentiates further with neoplastic progression and acquires Mtillerian duct-derived epithelial properties. I tested the hypothesis that growth and differentiation in ovarian carcinogenesis are regulated by HOX genes.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30974
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Fish analysis of chromosomal aneuploidies in spermatozoa from severely infertile men undergoing intracytoplasmic sperm injection (ICSI)

https://libraries.phsa.ca/permalink/catalog113969

http://hdl.handle.net/2429/16195

Gao, Haijun. Vancouver, BC: University of British Columbia , 2004. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematic…
Title
Fish analysis of chromosomal aneuploidies in spermatozoa from severely infertile men undergoing intracytoplasmic sperm injection (ICSI)
Author
Gao, Haijun
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2004
Topics
Faculty of Medicine
Theses
Abstract
The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematically investigated by standard methods with large sample sizes required to present significance.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/16195
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells

https://libraries.phsa.ca/permalink/catalog113965

http://hdl.handle.net/2429/18509

Choi, Jung-Hye. Vancouver, BC: University of British Columbia , 2006. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is as…
Title
Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells
Author
Choi, Jung-Hye
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2006
Topics
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is associated with the development and progression of ovarian cancer. Exposure to excess gonadotropins and leptin, related to menopause or infertility therapy and obesity, respectively, has been implicated as a risk factor for ovarian cancer.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/18509
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb

https://libraries.phsa.ca/permalink/catalog113991

http://hdl.handle.net/2429/9896

Knight, Kathleen Elizaabeth. Vancouver, BC: University of British Columbia , 1998. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little …
Title
Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb
Author
Knight, Kathleen Elizaabeth
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1998
Topics
Faculty of Medicine
Theses
Abstract
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little research attention. Because the hindlimb is composed of skin, bone, and skeletal muscle, it is representative of the carcass
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/9896
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://libraries.phsa.ca/permalink/catalog113953

http://hdl.handle.net/2429/30021

Poon, Song Ling. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
Title
Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role
Author
Poon, Song Ling
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30021
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons REF Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Implications of BRCA-loss phenotype in epithelial ovarian carcinoma

https://libraries.phsa.ca/permalink/catalog113964

http://hdl.handle.net/2429/32234

Press, Joshua Zephyr. Vancouver, BC: University of British Columbia , 2006. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unsel…
Title
Implications of BRCA-loss phenotype in epithelial ovarian carcinoma
Author
Press, Joshua Zephyr
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2006
Topics
Faculty of Medicine
Theses
Abstract
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unselected, consecutive series 49 non-mucinous, invasive EOC. BRCAl-loss was found in 21/49 tumors (43%).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/32234
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Influences of endocrine and autocrine factors in normal and neoplastic ovarian surface epithelium

https://libraries.phsa.ca/permalink/catalog113974

http://hdl.handle.net/2429/13688

Choi, Kyung-Chul. Vancouver, BC: University of British Columbia , 2001. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death i…
Title
Influences of endocrine and autocrine factors in normal and neoplastic ovarian surface epithelium
Author
Choi, Kyung-Chul
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2001
Topics
Faculty of Medicine
Theses
Abstract
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death in gynecological malignancies. Repeated ovulation contributes to neoplastic transformation of OSE, indicating that the process of healing ruptured OSE may contribute to the disease. Therefore, it has been hypothesized that endocrine and autocrine factors may influence the occurrence of ovarian tumors in women.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/13688
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Inhibition of pulsatile luteinizing hormone release by atrial natriuretic peptide and brain natriuretic peptide in the ovariectomized rat

https://libraries.phsa.ca/permalink/catalog113992

http://hdl.handle.net/2429/29412

Zhang, Jin. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Atrial natriuretic peptide (ANP) of atrial myocyte origin, has been shown to play a role in the diuresis, natriuresis, and antagonism of angiotensin and vasopressin. However, it is now apparent that in addition to the production of the peptide in the heart and in its role in fluid and electrolyte h…
Title
Inhibition of pulsatile luteinizing hormone release by atrial natriuretic peptide and brain natriuretic peptide in the ovariectomized rat
Author
Zhang, Jin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Atrial natriuretic peptide (ANP) of atrial myocyte origin, has been shown to play a role in the diuresis, natriuresis, and antagonism of angiotensin and vasopressin. However, it is now apparent that in addition to the production of the peptide in the heart and in its role in fluid and electrolyte homeostasis, it is also produced in the central nervous system participating in the regulation of pituitary hormone secretion. Administration of ANP through both central and peripheral routes has been shown to inhibit secretion of luteinizing hormone (LH) in the gonadectomized rat model.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29412
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Investigation of confined placental mosaicism and aberrant H19/ IGF2 imprinting in pregnancies conceived by in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)

https://libraries.phsa.ca/permalink/catalog113955

http://hdl.handle.net/2429/33832

Chan Wong, Edgar Antonio. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. H…
Title
Investigation of confined placental mosaicism and aberrant H19/ IGF2 imprinting in pregnancies conceived by in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)
Author
Chan Wong, Edgar Antonio
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. However, IVF and ICSI have been associated with increased risks of adverse perinatal health outcomes. The higher risk of low birth weight, intrauterine growth restriction, and small for gestational age are of special concern due to its association with adult-onset diseases. In this thesis project, the effect of ART on the genetic and epigenetic status of the placenta, and their associations with fetal growth restriction are examined.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/33832
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://libraries.phsa.ca/permalink/catalog113947

http://hdl.handle.net/2429/31191

Sakian, Sina. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Title
Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)
Author
Sakian, Sina
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/31191
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone

https://libraries.phsa.ca/permalink/catalog113952

http://hdl.handle.net/2429/34980

Chen, Junling. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
Title
Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone
Author
Chen, Junling
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/34980
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells

https://libraries.phsa.ca/permalink/catalog113978

http://hdl.handle.net/2429/6315

Chen, Victor. Vancouver, BC: University of British Columbia , 1997. (Thesis) — 2 copies, 2 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type…
Title
Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells
Author
Chen, Victor
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1997
Topics
Faculty of Medicine
Theses
Abstract
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6315
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Maternal leukocyte CD markers, apoptosis and band forms in preeclampsia

https://libraries.phsa.ca/permalink/catalog113970

http://hdl.handle.net/2429/14664

Fuchisawa, Akiko. Vancouver, BC: University of British Columbia , 2003. (Thesis) — 4 copies, 4 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Inter…
Title
Maternal leukocyte CD markers, apoptosis and band forms in preeclampsia
Author
Fuchisawa, Akiko
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2003
Topics
Faculty of Medicine
Theses
Abstract
Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Interestingly, normotensive intrauterine growth restriction also shows the same defect of placentation. In preeclampsia, the maternal syndrome develops from a number of alternative pathways leading to uteroplacental mismatch and, consequently, the release of endothelium-activating factors. This research is focused on neutrophil activation and the hypothesis for this research was that maternal neutrophils and monocytes are inappropriately activated in preeclampsia but not in normotensive intrauterine growth restriction.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/14664
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 2 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 3 BC Children's and Women's Study & Learning Commons Thesis Shelf Available
Copy 4 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The maternal predisposition to the syndrome of pre-eclampsia

https://libraries.phsa.ca/permalink/catalog113968

http://hdl.handle.net/2429/15429

Alasaly, Kadria A. Vancouver, BC: University of British Columbia , 2004. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine …
Title
The maternal predisposition to the syndrome of pre-eclampsia
Author
Alasaly, Kadria A.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2004
Topics
Faculty of Medicine
Theses
Abstract
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine growth restriction (IUGR). IUGR can occur in isolation, so-called normotensive IUGR. What is poorly understood is that some women develop the maternal syndrome of pre-eclampsia whilst others have only the fetal syndrome (normotensive IUGR), despite the fact that the initiating event in both is believed to be reduced uteroplacental perfusion.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/15429
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Maternal progesterone and fetal cortisol responses to hypoxemia in pregnant sheep

https://libraries.phsa.ca/permalink/catalog113981

http://hdl.handle.net/2429/4269

Wu, Li-Hua. Vancouver, BC: University of British Columbia , 1996. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and i…
Title
Maternal progesterone and fetal cortisol responses to hypoxemia in pregnant sheep
Author
Wu, Li-Hua
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1996
Topics
Faculty of Medicine
Theses
Abstract
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and its contents. However, while there have been many studies on the effects of hypoxemia on fetal cardiovascular, metabolic and endocrine functions, there are limited data on the effects of reduced oxygenation on placental endocrine activities. In the present study, we examined the effects of acute (2-h) moderate (maternal Pao₂ lowered by 27-35%, n=5) and severe (maternal Pao₂ lowered by 41-58%, n=4) hypoxemia on placental progesterone output into the maternal circulation in 7 chronically instrumented pregnant sheep (125 to 136 d). Hypoxemia was achieved by lowering maternal inspired O₂ concentration and the hypoxemia period was preceded and followed by 2 h pre-hypoxia and recovery periods, respectively. Control experiments (n=4), involving 6 h periods of normoxia were also carried out.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/4269
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

http://hdl.handle.net/2429/1228

Ferguson, Kyle Akira. Vancouver, BC: University of British Columbia , 2008. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population…
Title
Meiotic defects in infertile men
Author
Ferguson, Kyle Akira
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2008
Topics
Faculty of Medicine
Theses
Abstract
While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population may produce higher rates of aneuploid sperm. Thus, we hypothesized that defects in early meiotic events may contribute to both male infertility and the production of aneuploid sperm.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/1228
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The molecular biology of calbindin-D9k

https://libraries.phsa.ca/permalink/catalog113987

http://hdl.handle.net/2429/1766

Jeung, Eui-Bae. Vancouver, BC: University of British Columbia , 1993. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calb…
Title
The molecular biology of calbindin-D9k
Author
Jeung, Eui-Bae
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1993
Topics
Faculty of Medicine
Theses
Abstract
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calbindin-D9k at the cDNA and genomic level. The cDNAs for the bovine, murine, and ratcalbindin-D9k as well as the gene for rat calbindin-D9k had been cloned previously.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/1766
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

A morphological investigation of the effects of pregnant mare serum gonadotrophin on oocyte maturation, fertilization and embryonic development in rats

https://libraries.phsa.ca/permalink/catalog113990

http://hdl.handle.net/2429/30962

Britton, Ann Patricia. Vancouver, BC: University of British Columbia , 1991. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic a…
Title
A morphological investigation of the effects of pregnant mare serum gonadotrophin on oocyte maturation, fertilization and embryonic development in rats
Author
Britton, Ann Patricia
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1991
Topics
Faculty of Medicine
Theses
Abstract
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30962
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://libraries.phsa.ca/permalink/catalog113946

http://hdl.handle.net/2429/43273

Asghari Roodsari, Alaleh. Vancouver, BC: University of British Columbia , 2012. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Title
Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy
Author
Asghari Roodsari, Alaleh
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Topics
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/43273
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta

https://libraries.phsa.ca/permalink/catalog113994

http://hdl.handle.net/2429/29416

Little, Marie-Terese E. Vancouver, BC: University of British Columbia , 1990. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol…
Title
The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta
Author
Little, Marie-Terese E.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1990
Topics
Faculty of Medicine
Theses
Abstract
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol metabolism can be manipulated in early life. Therefore, studies of the developmental patterns of the key enzymes in cholesterol metabolism are of great importance. Acyl coenzyme A: cholesterol acyltransferase (ACAT) is the primary enzyme which catalyzes the conversion of free cholesterol to cholesterol esters in cells.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/29416
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://libraries.phsa.ca/permalink/catalog113967

http://hdl.handle.net/2429/16421

Astanehe, Arezoo. Vancouver, BC: University of British Columbia , 2005. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
Title
Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis
Author
Astanehe, Arezoo
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2005
Topics
Faculty of Medicine
Theses
Abstract
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/16421
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.

https://libraries.phsa.ca/permalink/catalog113957

http://hdl.handle.net/2429/6844

Menzies, Jennifer Marie. Vancouver, BC: University of British Columbia , 2009. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to s…
Title
The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.
Author
Menzies, Jennifer Marie
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2009
Topics
Faculty of Medicine
Theses
Abstract
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6844
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The prediction of adverse maternal outcomes in pre-eclampsia

https://libraries.phsa.ca/permalink/catalog113966

http://hdl.handle.net/2429/16403

Devarakonda, Rajashree M. Vancouver, BC: University of British Columbia , 2005. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility …
Title
The prediction of adverse maternal outcomes in pre-eclampsia
Author
Devarakonda, Rajashree M.
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2005
Topics
Faculty of Medicine
Theses
Abstract
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility of developing a severity score that can predict adverse maternal outcome.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/16403
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Profiling the vaginal microbiome in HIV-positive women

https://libraries.phsa.ca/permalink/catalog113942

http://hdl.handle.net/2429/44267

Mahal, Daljeet Singh. Vancouver, BC: University of British Columbia , 2013. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Title
Profiling the vaginal microbiome in HIV-positive women
Author
Mahal, Daljeet Singh
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2013
Topics
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/44267
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell

https://libraries.phsa.ca/permalink/catalog113976

http://hdl.handle.net/2429/6811

Vaananen, Jeffrey Eric. Vancouver, BC: University of British Columbia , 1997. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
Title
Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell
Author
Vaananen, Jeffrey Eric
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1997
Topics
Faculty of Medicine
Theses
Abstract
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6811
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Recombinant human activated protein C as a therapy for pre-eclampsia

https://libraries.phsa.ca/permalink/catalog113962

http://hdl.handle.net/2429/32051

Peng, Gang. Vancouver, BC: University of British Columbia , 2007. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflamma…
Title
Recombinant human activated protein C as a therapy for pre-eclampsia
Author
Peng, Gang
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2007
Topics
Faculty of Medicine
Theses
Abstract
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflammatory response syndrome) has drawn attention to the possible use of this medicine for other conditions. Pre-eclampsia, has remarkable similarity to SIRS and may be such a condition.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/32051
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://libraries.phsa.ca/permalink/catalog113954

http://hdl.handle.net/2429/30478

Wen, Jiadi. Vancouver, BC: University of British Columbia , 2010. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Title
Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology
Author
Wen, Jiadi
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2010
Topics
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/30478
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulation of androgen action by sex hormone-binding globulin

https://libraries.phsa.ca/permalink/catalog113948

http://hdl.handle.net/2429/35861

Hong, Eui-ju. Vancouver, BC: University of British Columbia , 2011. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Title
Regulation of androgen action by sex hormone-binding globulin
Author
Hong, Eui-ju
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2011
Topics
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/35861
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulation of cytochrome P450 and P450 mRNA in human granulosa-luteal cells

https://libraries.phsa.ca/permalink/catalog113984

http://hdl.handle.net/2429/3482

Ge, Hong. Vancouver, BC: University of British Columbia , 1994. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hor…
Title
Regulation of cytochrome P450 and P450 mRNA in human granulosa-luteal cells
Author
Ge, Hong
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1994
Topics
Faculty of Medicine
Theses
Abstract
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hormone biosynthesis.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/3482
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Regulation of rat ovarian gonadotropin Releasing hormone receptor mRNA levels

https://libraries.phsa.ca/permalink/catalog113977

http://hdl.handle.net/2429/6615

Vaananen, Celine Claire. Vancouver, BC: University of British Columbia , 1997. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
The studies undertaken herewithin sought to characterize the pattern of regulation of the gonadotrophin-releasing hormone receptor (GnRH-R) mRNA levels in the rat ovary. The demonstration of gonadotrophin-releasing hormone (GnRH) transcripts in steroidproducing and steroid-dependent tissues suggest…
Title
Regulation of rat ovarian gonadotropin Releasing hormone receptor mRNA levels
Author
Vaananen, Celine Claire
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1997
Topics
Faculty of Medicine
Theses
Abstract
The studies undertaken herewithin sought to characterize the pattern of regulation of the gonadotrophin-releasing hormone receptor (GnRH-R) mRNA levels in the rat ovary. The demonstration of gonadotrophin-releasing hormone (GnRH) transcripts in steroidproducing and steroid-dependent tissues suggests that GnRH may be implicated in the modulation of steroid action in those target tissues. Expression of GnRH-R mRNA increases in gonadal tissues and the pituitary with age, supporting the concept of GnRH as a local regulator in the developing rat as well as in the adult.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/6615
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The role for insulin-like growth factor-I in preimplantation embryonic development and decidualization following superovulation in the rat

https://libraries.phsa.ca/permalink/catalog113980

http://hdl.handle.net/2429/4814

Katagiri, Seiji. Vancouver, BC: University of British Columbia , 1996. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation…
Title
The role for insulin-like growth factor-I in preimplantation embryonic development and decidualization following superovulation in the rat
Author
Katagiri, Seiji
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1996
Topics
Faculty of Medicine
Theses
Abstract
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation in the rat. IGF-I may be beneficial to preimplantation embryonic development. IGF-I stimulated embryonic development and metabolism in vitro and increased the rate of implantation and fetal development when the blastocysts were transferred into a receptive uterus.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/4814
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

The role of norepinephrine in the neuroendocrine regulation of luteinizing hormone release in the rat

https://libraries.phsa.ca/permalink/catalog113999

http://hdl.handle.net/2429/28623

Bergen, Hugo Theodore. Vancouver, BC: University of British Columbia , 1988. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
An excitatory role for norepinephrine (NE) in the regulation of luteinizing hormone (LH) release was first suggested when it was demonstrated that noradrenergic receptor antagonists were able to block ovulation. More recently it has been proposed that NE has both an excitatory role and an inhibitor…
Title
The role of norepinephrine in the neuroendocrine regulation of luteinizing hormone release in the rat
Author
Bergen, Hugo Theodore
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
1988
Topics
Faculty of Medicine
Theses
Abstract
An excitatory role for norepinephrine (NE) in the regulation of luteinizing hormone (LH) release was first suggested when it was demonstrated that noradrenergic receptor antagonists were able to block ovulation. More recently it has been proposed that NE has both an excitatory role and an inhibitory role in the neuroendocrine regulation of LH release. The excitatory effects may be mediated by alpha-adrenergic receptors and the inhibitory effects may be mediated via beta-adrenergic receptors. These experiments were performed to better understand the role of NE, the receptor type through which NE exerts its effects, and the role of the two major NE pathways in the brain, on LH secretion in the rat.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/28623
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://libraries.phsa.ca/permalink/catalog113944

http://hdl.handle.net/2429/42242

So, Wai Kin. Vancouver, BC: University of British Columbia , 2012. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Title
Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells
Author
So, Wai Kin
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2012
Topics
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/42242
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

Roles of Confined Placental Mosaicism (CPM) and H19/IGF2 imprinting in pregnancies derived from intracytoplasmic sperm injection (ICSI)

https://libraries.phsa.ca/permalink/catalog113961

http://hdl.handle.net/2429/32719

Hatakeyama, Chiho. Vancouver, BC: University of British Columbia , 2007. (Thesis) — 1 copy, 1 available
Audience
Professional
Agency
BC Children's and Women's
Location
Study & Learning Commons
Call Number
Thesis Shelf
In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormaliti…
Title
Roles of Confined Placental Mosaicism (CPM) and H19/IGF2 imprinting in pregnancies derived from intracytoplasmic sperm injection (ICSI)
Author
Hatakeyama, Chiho
Place
Vancouver, BC
Publisher
University of British Columbia
Year Published
2007
Topics
Faculty of Medicine
Theses
Abstract
In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormalities, and imprinting disorders. However, the underlying causes remain unknown.
Language
English
Material Type
Thesis
Agency
BC Children's and Women's
Location
Study & Learning Commons
URL
http://hdl.handle.net/2429/32719
Audience
Professional
Call Number
Thesis Shelf
Copy 1 BC Children's and Women's Study & Learning Commons Thesis Shelf Available

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